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Tryptophan Hydroxylase 2 (TPH2)
| Variant | Association | Phenotype | Sample Information | Author |
|---|---|---|---|---|
| rs1386483 | Genotypic: + TT χ2 = 5.04; P = 0.025; OR = 0.33, 95%CI (0.12; 0.93) negative alcohol before suicide. | Suicide completers | Etnicity: Polish | Fudalej, 2009 |
| Cases: 162 suicide completers | ||||
| Notes: Also investigated: A218C (TPH1); ACE I/D and 5HTTLPR | ||||
| rs6582071 rs450625 rs11178997 rs11178998 rs11178999 rs1386494 rs1386493 rs1386491 rs7305115 rs1386498 rs1487278 rs11179044 rs4290270 rs11179064 rs17110747 | Allelic: ns Haplotypic: ns Genotypic: ns |
Suicide completers | Etnicity: japanese | Mouri, 2009 |
| Controls: 260 volunteers M=162:mean age:39.5 ±15.9; F=98: mean age: 46.5±15.3. | ||||
| Suicides:234 completers, M=156, mean age 47.1 ±13.2, F= 78, mean age 46.7±19.2 | ||||
| rs4760813 rs3935748 rs6582071 rs10748186 rs17110489 rs7955501 rs1386494 rs10748189 rs4760820 rs1487275 rs1386483 rs10879357 rs17110747 rs1872824 | Allelic: ns Haplotypic: ns |
Suicide Completers | Etnicity: Estonian | Must, 2009 |
| Controls: 327 volunteers, men, mean age 40.5 ± 14.49 | ||||
| Suicide: 288 males, mean age 42.8 ±13.69 | ||||
rs1386493 |
Allelic: .003 |
Suicides or major depression | Ethnicity: Caucasian | Haghighi 2008 |
| Cases: 82 patients with major depression(M:61%;suicides: 72; mean age: 49.8+18.7) or only suicide (n:4) | ||||
| g.22897A>G | Allelic: .05 | 80 controls without major depression or suicide | ||
Haplotypic (rs1386493, g.22897A>G, rs1386494):+,CGG, p=.01 |
Notes: the two variants associated with major depression and not with suicide alone | |||
|
Allelic: ns Genotypic: ns |
Suicide attempts | Ethnicity: Caucasian [N=529 (94%)], Asian [N=26 (4.6%)], or multiple ethnic identities [N=8 (1.4%)] |
Mann 2007 | Cases: bipolar [n:109, M:61%, ages: 22-90] and major depressive patients [n:324], including 187 suicide attempters | Healthy controls: bipolar [n:130, M:61%, ages: 22-90] | Genotypic:+,CG, p<.001, in major depressive patients with childhood abuse | Suicidal ideas | Notes: CG genotype interaction with childhood abuse also related to increased depression and lifetime impulsivity scores; no association with depressive disorders or CSF levels of 5-HIAA, HVA, or MHPG |
hCV8376173, hCV245410, rs1487280
|
Allelic: ns | Suicidal behaviour severity | Cases: 336 (F:62%) bipolar patients from 305 nuclear families (mean age: 35.36± 10.37 SD), including 267 patients with histories of suicide ideas or attempts | De Luca, 2007 |
| Notes: suicidality assessed quantitatively and coded as follows: 0 = absence of suicide/death thoughts, 1 = thoughts of death, 2 = suicide ideation, 3 = suicide plan, 4 = suicide attempt; | ||||
| rs1386494 | Allelic: ns | Suicide attempts | Cases: 2018 bipolar patients and families (F:64%, including 548 suicide attempters): Sample 1: N:1405; Sample 2: N: 613; | Lopez, 2007 | rs1007023 | Allelic: ns | rs9325202 | Allelic: ns | Notes: analyses done in each sample separately and together. Observed the same haplotypic association with bipolar disorder suggesting that this haplotype is not an independent risk factor for suicide attempts. | Haplotypic: +, GTA, OR 1.2 95%CI 1.0-1.5 |
| 20 intronic SNPs | Allelic: ns |
Suicide attempts | Ethnicity: German |
ZIll, 2007 |
| Cases: 353 (F:79; mean age: 42.7+9.7) alcohol-dependent patients, including 102 suicide attempters, 58 of whom used violent means |
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| Ethnicity-matched controls: 305 (F:141;mean age: 40.05+15.2) | rs7305115 | Allelic: -,A, p=.0067 Genotypic: -, AA, p=.0033 |
Suicide attempts | Ethnicity: Han Chinese, Shadong | Ke, 2006 | Cases: depressed suicide attempters: N: 102 (F: 61); mean age: 33.01 ±12.12 | Controls: non-attempting depressed patients: N:123 (F:54);mean age: 33.26±14.36 |
473TA |
Allelic : ns |
Suicide attempts or suicidal behavior | Cases: schizophrenic patients [(n: 253 (F: 33%) mean age: 41±10.7] including 83 suicide attempters and 157 ideators/attempters) | De Luca, 2005 |
| hCV245410 | Allelic : ns | |||
| Haplotypic: ns | ||||
| hCV245410 | Allelic: ns | Suicide attempts or suicidal behavior | Cases: 336 bipolar patients (including 86 suicide attempters and 267 ideators) from 305 families: F:62%, mean age: 35±10 | De Luca 2004 | hCV8376173 | Allelic: ns | Notes: suicidality assessed on a quantitative scale from suicidal thoughts, through ideation, and plans, to suicide attempts | rs1487280 | Allelic: ns | Haplotypic: ns |
| 14 SNPs | Genotypic: +, rs4448731(TT), OR 5.3 95% CI 1.7-16.4 | Suicide | Ethnicity: French Canadian | Lopez de Lara, 2007 |
| Cases: 259 depressed subjects, including 114 depressed suicides (F:16; mean age: 41.6±14.6) | ||||
| Genotypic:+, rs4641527(GG), OR 5.2 95% CI 1.7-16.0 | Controls: 145 depressed nonsuicidal patients (F:21, mean age: 41.4±10.2) | |||
| Haplotypic: multiple | Notes: alleles T, G, G, and C of SNPs rs4448731, rs6582071, rs4641527, and rs1386497, respectively, were overrepresented in depressed suicides, as were homozygotes for the T allele of rs4448731, the G allele of rs4641527, and carriers of the C allele of rs1386497. GG homozygotes ( rs4641527) had lower reward dependence but there was no support for mediation by impulsive aggressive behaviors; Bonferroni-corrected | |||
473TA |
Genotypic: ns |
Suicide | Cases: suicide completers (n:22; F:11) with schizophrenia (n:6) or bipolar disorder (n:16): mean age: 42.73±9.90 |
|
8396GC | Genotypic: ns | Controls: individuals with schizophrenia (n: 29) and bipolar patients (n: 18) dying from non-suicide-related causes (F: 15): mean age: 44.98±9.37 | Haplotypic: ns |
| 10 SNPs | Allelic: +, Rs1386494(G), p=.038 | Suicide | Ethnicity: Caucasian, Southern Germany | Zill, 2004 |
| Cases: suicide victims: F: 72; M: 191; mean age:47.1±18.1; 217 used violent means; | ||||
| Healthy general population controls matched for ethnicity: M: 138, F:128; 39.7±15.3; | ||||
| Notes: tested 10 SNPs; found 3 major haplotypes; haplotypic associations with suicide disappeared after Bonferoni correction | ||||
Haplotypic: ns |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males